Advertisement These medications have been shown to help patients lose 15% to 20% of their body weight, says Dr
In a landmark Phase 2 obesity trial, participants receiving the highest dose achieved: Up to ~24% average weight loss at 48 weeks Weight loss had not yet plateaued at the end of the study Potential for even greater reductions with longer treatment duration For context: Semaglutide (GLP-1): ~15% weight loss Tirzepatide (GIP + GLP-1): ~2123% weight loss Retatrutide (GIP + GLP-1 + Glucagon): ~24%+ weight loss in Phase 2 studies Common side effects were similar to other GLP-1based therapies and included nausea, vomiting, diarrhea, constipation, and abdominal discomfort, primarily during dose escalation
Counter to this attitude was the emergence of the body positivity movement in the 2010s that sought to promote self-acceptance, celebrate body shape diversity, and prioritize metabolic health, challenging the use of BMI or weight as sole indicators of health without considering the broader context (Gailey, 2022
(2008) The association of testosterone levels with overall sleep quality, sleep architecture, and sleep-disordered breathing
You should use them alongside a nutrition and lifestyle program such as the Mayo Clinic Diet for Weight-Loss Medication program
