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Monitoring: Metabolic: Monitor for signs/symptoms of hypoglycemia GI: Monitor for signs/symptoms of pancreatitis after starting therapy Renal: Monitor renal function in patients with renal dysfunction reporting severe adverse GI reactions (especially when starting or escalating doses) Patient advice: Read the US FDA-approved patient labeling (Medication Guide and Instructions for Use)

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10.1007/s13105-022-00939-9 18 EdwardsC

Another GLP-1/GIP/glucagon receptor triagonist known as retatrutide (previously LY3437943) was developed by Eli Lilly in 2022 leading to weight loss, reduced fat mass, decreased blood glucose and insulin levels in obese mice, which was attributed to increased energy expenditure and lipid oxidation [62]