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This review synthesizes insights into metal transporters to advance our understanding of their roles in maintaining systemic and brain Mn homeostasis under healthy conditions and their contribution to Mn dysregulation in disease states, particularly neurological disorders

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Vasodilation provides up to 25 -50 times resting levels of local blood flow by means of relaxation of the smooth arterial musculature and of the sphincter allowing flow into the capillary bed [9]

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