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For individuals living with complex, chronic conditions like Long COVID, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), dysautonomia, and mast cell activation syndrome (MCAS), the gut is frequently a site of profound dysfunction

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Experimental studies indicate that calycosin may modulate the Toll-like receptor (TLR) 4/NF-B signaling pathway, suppress the expression of TSLP and IL-33, and increase tight junction proteins such as ZO-1 and occludin in both human immortalized keratinocyte cell line (HaCaT) and mouse AD models (Tao et al., 2017)

This will play an important role in reducing any risks associated with these foods or supplements

Statements Author contributions Writing the manuscript: LS, FW, and DZ