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A PUF hub drives self-renewal in Caenorhabditis elegans germline stem cells

The treatment helped reduce hunger, slow digestion and enhance fullness, making lifestyle and nutrition changes easier to maintain

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These gastrointestinal effects typically diminish as the body adjusts

Rather, the majority of orally ingested l-carnitine in mice produced a previously unappreciated intermediary metabolite, -butyrobetaine (BB), in a gut microbiotadependent step that occurred at a site anatomically proximal to, and at a rate 1,000-fold higher than the rate of the formation of TMA (26)