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Other drugs like octreotide (somatostatin agonist) and bromocriptine (dopamine agonist) can be used to block GH secretion because both somatostatin and dopamine negatively inhibit GHRH-mediated GH release from the anterior pituitary
Patients with favorable GLP1R or GIPR predispositions may achieve clinical goals at lower doses and costs, while those with FTO or MC4R variants may require higher doses or dual-agent compoundschanging the true cost-per-outcome calculation significantly
Serious side effects are possible with either drug, including serious allergic reactions and low blood sugar (hypoglycemia)
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SAFETY AND EFFICACY CONCERNS RAISED BY THE FDA, AUSTRALIAN GOVERNMENT, AND BIG PHARMA AFTER FIVE DIE ON COMPOUNDED GLP-1 DRUGS, AND OTHERS REPORT SERIOUS SIDE EFFECTS Despite allowing compounding, the FDA has expressed concerns about GLP-1 knockoffs
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