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Contraindications Do Not Use If You Have a known hypersensitivity to any component of the formulation Have a history of kidney stones (high-dose vitamin C can increase oxalate and kidney stone risk) Have hereditary hemochromatosis or iron overload (vitamin C enhances iron absorption) Have glucose-6-phosphate dehydrogenase (G6PD) deficiency (high-dose IV vitamin C can cause hemolysis) Have severe kidney disease Are pregnant or breastfeeding (without specific medical supervision) Warnings and Precautions G6PD deficiency: High-dose vitamin C can cause red blood cell hemolysis in patients with G6PD deficiency