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People who are addicted to nicotine find it very difficult to quit, with the World Health Organization reporting that, of the nicotine users who try to give it up, only 4% will succeed without support

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9 A 2013 Vanity Fair article about the NuvaRing contraceptive stated that the FDA had determined it had a 56% increased risk of blood clots over earlier birth control pills

50 Human studies may have limited results due to short-term exposure study and potential harm from long-term use may be underestimated