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Quick Answer: The exact mechanism by which GLP-1 receptor agonists might cause pancreatitis remains unproven, though proposed pathways include indirect effects through increased gallbladder disease risk rather than direct pancreatic toxicity

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"Such as when people with eating disorders might be ambivalent about recovery or whether they want to change," she said

A subsequent study describing the double incretin knock-out (DIRKO) mice showed that male Glp-1r / mice are only mildly glucose intolerant while females exhibited normal glucose tolerance after being backcrossed for five generations onto the C57BL/6 strain [5]