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Excess glucocorticoids (GCs) can induce neuronal damage in brain regions such as the hippocampus and SN through several mechanisms, including mitochondrial dysfunction, inhibition of inhibitory and excitatory synaptic transmission, and disruption of microglial or astrocytic functions, thereby exacerbating the progression of PD ( 2.3 The close relationship between intestinal microbiota and PD In the 1980s, the first reports of Lewy body pathology in the ENS provided evidence for ENS and gut microbiota dysfunction in PD ( Lachnospira and Butyricicoccus ) and butyrate-producing [Eubacterium]_ventriosum_ group ( Proteobacteria, Verrucomicrobia, and Actinobacteria ) and five genera ( Akkermansia , Enterococcus , Hungatella , and two Ruminococcaceae ) in their gut microbiome
This can lead to gallstone formation, which can block the release of bile, leading to the inflammation of the gallbladder
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Dont use too much though or youll get that sticky feeling
