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Of note, there is an approximately 23-fold increased risk of acute pancreatitis in people with T2D, compared with those without T2D [13]

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Some scholars have discovered by knocking out the mouse SQSMT1 gene that SQSTM1 mediates ULK1 phosphorylation to activate autophagy and promote the formation of AMPK-ULK1-SQSTM1 complex, which leads to autophagic Keap1 degradation and activates the non-canonical Keap1-Nrf2 pathway, thereby protecting mouse liver from lipotoxicity (Figure 4) (Figure 4) (Yan et al., 2018a

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