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doi: 10.1007/s00210-023-02939-y

In contrast to pure -opioid agonists, eluxadoline, a little-absorbed combined - and -opioid receptor agonist and -opioid receptor antagonist, was developed to decrease constipation and boost analgesic effectiveness ( The mechanism of action of the selective 5-HT3 antagonist alosetron is thought to be both centrally and peripherally mediated ( In clinical practice, antispasmodics are frequently used for alleviating IBS-related abdominal pain

Additionally, it promotes the regeneration of other antioxidants, such as vitamin E