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* Correspondence: Eva Liebau, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Iron-dependent ALOX enzymes can generate ROS to catalyze the oxidation of polyunsaturated fatty acids (PUFAs) ( 2+ is released in the cell by degradation, which promotes ferroptosis (Hou et al., 2016)

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As the endothelium emerge as a key factor in the constant activation of adhesion molecules in sickle RBCs, these adhesion molecules present a very attractive therapeutic target

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