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A more recent transcriptome study on the E15.5 brains of control and Nsd2 KO mice revealed that the loss of NSD2 caused dysregulation of genes related to synaptic transmission and formation ( Nsd2 KO brains, the loss of NSD2 did not wholly deplete H3K36me2, suggesting that NSD1 and NSD2 redundantly contribute to the broad H3K36me2 pattern in the nervous system ( 1.3 ASH1L ASH1L (Absent, Small, or Homeotic Discs-1-Like) is a histone methyltransferase that plays a crucial role in neurodevelopment by regulating gene expression through catalyzing the mono- and di-methylation of H3K36 ( Hox genes

Its used in muscle repair and reduces wasting, particularly in ageing or illness-related muscle loss

American Heart Association, 2021