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Pathophysiological changes in astroglia can be primary or secondary and can result in gain or loss of functions

While we cannot reproduce clinical photographs from the cited studies without permission, we can describe what the published cases document: Patil and Mitra (2026) describe tongue hyperpigmentation in the context of Addison's disease - typically presenting as diffuse darkening of the tongue surface, often alongside pigmentation of other mucosal surfaces and skin creases

Your provider may also prescribe zinc if you have Wilson disease but dont have symptoms

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A healthier scalp encourages better hair growth