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Once activated, microglia undergo various morphological changes, such as the thickening and retraction of ramifications, the exposure of MHC I/II proteins, the expression of immune molecules, and the secretion of cytotoxic factors, recruitment molecules, and proinflammatory molecules, leading to a proinflammatory cascade [56], which is accompanied by increased proliferation [57, 58]

Structure, origin, and position in current peptide research literature

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As with doxorubicin, cisplatin treatment also results in ROS generation, which is neutralised by the NADPH-powered glutathione system, warranting investigation of this strategy for other forms of chemotherapy which are detoxified via this system