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Figure 1 The highly conserved mechanistic target of rapamycin (mTOR) regulates protein synthesis, metabolism and growth

Upon binding of a ligand to a death receptor, Fas-associated death domain protein (FADD) is recruited and the death-inducing signaling complex (DISC) (for FasL/FasR, TRAIL/TRAIL-R1 or TRAIL-R2) or complex II (in the case of TNF/TNF-R1) is formed

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[DOI] [PubMed] [Google Scholar] 36.Speir M., Nowell C.J., Chen A.A., O'Donnell J.A., Shamie I.S., Lakin P.R., D'Cruz A.A., Braun R.O., Babon J.J., Lewis R.S., Bliss-Moreau M., Shlomovitz I., Wang S., Cengia L.H., Stoica A.I., Hakem R., Kelliher M.A., O'Reilly L.A., Patsiouras H., Lawlor K.E., Weller E., Lewis N.E., Roberts A.W., Gerlic M., Croker B.A