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It was engineered in the 1990s at Monash University in Australia by a research group led by Frank Ng, with a very specific hypothesis: that the fat-mobilizing actions of growth hormone could be isolated from its other metabolic effects if you stripped the molecule down to the relevant fragment
As for significant weight management results, those tend to show up after a few months of consistent effort
PMID: 40789979 Chang CH, Tsai WC, Lin MS, et al
Conversely, medications like metformin, H2 blockers, and proton pump inhibitors can reduce the absorption of Vitamin B12
This data comes from animal models and may not translate directly to human physiology
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