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These medications target the GLP-1 pathway to help reduce appetite, increase satiety, and achieve significant weight loss

IGF-1 monitoring FDA labeling for tesamorelin recommends monitoring IGF-1 and considering discontinuation when elevations remain persistent

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Further flow cytometry analysis confirmed that caloric restriction modulates the PI3K/AKT/c-Myc signaling axis and reduces granulocyte-macrophage colony-stimulating factor (GM-CSF) production in Th17 cells, thereby promoting CD4 + T cell balance (127)

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