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In the Phase 2 trial published in the New England Journal of Medicine (2023), retatrutide was administered as a once-weekly subcutaneous injection using a structured dose-escalation schedule

Made up of small particles of biomaterials that are engineered to release little bursts of the regenerative drug over a long period of time, the injected drug aims to jumpstart cells to produce new cartilage tissue in the lab and possibly someday in humans

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