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This abnormal load distribution further impairs the mechanical function of the disc, transferring excessive stress to the annulus fibrosus, leading to its damage and contributing to pain 6,26
Altered AC levels in peripheral tissues may indicate systemic metabolic dysregulation affecting energy homeostasis and immune-metabolic pathways in depression [13]
37 Stimulating endogenous cardiomyocyte proliferation has been proposed as a more cautious yet promising approach, as direct activation of key signaling pathways has been shown to increase cardiomyocyte proliferation, despite the low basal turnover rate in adult mammalian hearts
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