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coli Escherichia coli Ex-4@DFO NPs Exendin-4 modified DFO nanoparticles Ex-4 Exendin-4 ER Endoplasmic reticulum EAE Experimental autoimmune encephalomyelitis EGFR Epidermal growth factor receptor FDA Food and Drug Administration FGF21 Fibroblast growth factor 21 FNDC5 Fibronectin type III domain-containing 5 FXR Farnesoid X receptor FUS Focused ultrasound GLP-1 Glucagon-like peptide-1 GLP-1R Glucagon-like peptide-1 receptor GPCR G protein-coupled receptor GIPR Gastric inhibitory polypeptide receptor GCGR Glucagon receptor GLP-1RAs GLP-1 receptor agonists GOx Glucose oxidase G4 Generation 4 GMBS 4-Maleimidobutyric acid N-hydroxysuccinimide ester GI Gastrointestinal GATA3 GATA Binding Protein 3 GFAP Glial fibrillary acidic protein GDNF Glial cell line-derived neurotrophic factor GlpNPs GLP-1R agonist liraglutide nanoparticle GMP Good manufacturing practices HSCs Hepatic stellate cells HbA1c Hemoglobin A1c HOMA-IR Homeostasis model assessment of insulin resistance HSPC Hydrogenated soybean phospholipids H&E Hematoxylin and eosin HFrEF Heart failure with reduced ejection fraction HFpEF Heart failure with preserved ejection fraction HFD High-fat diet HER2 Human epidermal growth factor receptor 2 IBD Inflammatory bowel disease IgG4 Fc Immunoglobulin G4 fragment crystallizable region lPEI Linear polyethylenimine Iba-1 Ionized calcium-binding adapter molecule 1 IVIS In vivo imaging system IL-3 Interleukin-3 IHC Immunohistochemistry IR Insulin resistance IL-10 Interleukin-10 kDa kilodalton LNPs Ionizable lipid NPs LDH Layered double hydroxide LRP1 Lipoprotein receptor-related protein 1 LV Left ventricular MMP Matrix metalloproteinase MASLD Metabolic dysfunction-associated steatotic liver disease MAPK Mitogen-activated protein kinase MCAo Middle cerebral artery occlusion MS Multiple sclerosis MTX Methotrexate mTOR Mammalian target of rapamycin MI Myocardial infarction MACE Major adverse cardiovascular events MPTP 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine MR Magnetic resonance MRI Magnetic resonance imaging mRNA Messenger ribonucleic acid NASH Non-alcoholic steatohepatitis NF-B Nuclear factor kappa-B NAFLD Non-alcoholic fatty liver disease NIR-II Near-infrared II NMPA National Medical Products Administration NPs Nanoparticles NET Neutrophil extracellular trap NOD mice Non-obese diabetic mice NA Nicotinamide NCI-NCL National Cancer Institute Nanotechnology Characterization Laboratory OXM Oxyntomodulin OL-NP PEG-PLGA NPs PSMA Prostate-specific membrane antigen PAT Process analytical technology PtdSer Phosphatidylserine PLA Polylactic acid PAS-CPP-GLP-1 Poly(allyl succinate)-cell penetrating peptide-glucagon-like peptide-1 pNETs Pancreatic neuroendocrine tumor PAD Peripheral arterial disease Phe Phenylephrine PDT Photodynamic therapy p-NF-B Phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells PBS Phosphate-buffered saline PMF Platelet membrane fragments PA-GLP-1 Palmitoylated GLP-1 PEI Polyethylenimine PEG NPs Polyethylene glycol-modified nanoparticles PAMAM Polyamidoamine PEG Polyethylene glycol PEGylated Polyethylene glycolated PLGA Poly(lactic-co-glycolic acid) PKA Protein kinase A PD Parkinsons disease QbD Quality by design ROS Reactive oxygen species rhGLP-1 Recombinant human glucagon-like peptide-1 SGLT2 Sodium-glucose co-transporter 2 SNAC Sodium N-(8-[2-hydroxybenzoyl]amino) caprylate SFEE Supercritical fluid extraction of emulsions SPIONs Superparamagnetic iron oxide NPs sEVs Small extracellular vesicles siRNAs Small interfering RNAs SNEDDS Self-nanoemulsifying drug delivery system SEM Scanning electron microscopy s.e.m

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