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Standardized dosing protocols, validated outcome measures, and comprehensive safety monitoring would establish the evidence base necessary for informed clinical decision-making

Medini H, Zirman A, Mishmar D

doi: 10.1002/jcp.22578

The mammalian ortholog, casein kinase 1 alpha (CSNK1A1), is known to prime substrates for E3 ligase recognition by phosphorylating short amino acid sequences called phospho-degrons, which leads to ubiquitination and rapid proteasomal degradation 70,76,77,87,89

Materials and methods Cell lines MCF-7 (HTB-22), T47-D (HTB-133), MDA-MB175VII (HTB-25), HCC1428 (CRL-2327), and BT-483 (HTB-121) cell lines were obtained from American Type Culture Collection (ATCC), MFM-223 (ACC 422), Cal-519 (ACC 302), and Cal-120 (ACC 459) cell lines were from Leibniz Institute DSMZ, and Sum149PT (HUMANSUM-0003004), Sum159PT (HUMANSUM-0003006) cell lines were from Bioivit