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In vivo studies with long-acting glucagon analogue suggest that hypoaminoacidaemia could be an important contributing mechanism to the observed increase in energy expenditure with glucagon agonism, but it also leads to enhanced lean mass loss [63]

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A University of Kansas study, which reviewed health records of nearly 150,000 patients, found a 66% increased diagnosis rate of gastroparesis among individuals treated with GLP-1s

This could also address an area of concern for roughly two-thirds of physicians who question whether non-traditional telehealth providers offer sufficient oversight when prescribing GLP-1s , per a December 2025 Sermo survey

Months 3 to 4: Measurable reduction in body fat percentage, particularly subcutaneous fat