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Furthermore, SGLT2i reduce circulating catecholamine levels [60] and impact myocardial remodeling and fibrosis, through modulation of several chemokine pathways (IL-6, TNF-, monocyte chemoattractant protein-1), calcium homeostasis [61, 62], authophagy [60, 63,64,65,66,67,68] and RAAS inhibition [69] in pre-clinical models

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