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VMAT2 exhibits higher affinity for monoamine substrates than does VMAT1, and VMAT2 is expressed in all monoaminergic neurons in the brain

Theoharides TC, et al

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Neuroprotective Properties Under Investigation The Zagreb groups 2016 review in Current Neuropharmacology described peripheral BPC-157 administration altering serotonin synthesis rates in specific brain regions, particularly nigrostriatal and other dopaminergic pathways (Tohyama, Sikiric, Diksic, 2004, Life Sciences )

High-Frequency Stimulation-Induced Peptide Release Synchronizes Arcuate Kisspeptin Neurons and Excites GnRH Neurons