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Those questions are especially important if you have a history of suicidal thoughts, bipolar disorder, seizures, bleeding risk, pregnancy, breastfeeding, or significant medication interactions

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Dry skin can be stubborn

Retatrutide is still investigational and not approved by any regulator as of April 2026, so everything below is presented as clinical-trial data, not as medical guidance

So I use 0.5 as my starting dose and I find that people tolerate it