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IGF-1 LR3 does not initiate cancer but can accelerate existing tumor growth through its anti-apoptotic and pro-proliferative mechanisms

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When stress hormones remain elevated for extended periods of time, they can contribute to inflammation and increased oxidative stress

Genetic susceptibility and environmental exposures promote early activation of lymphocytes in the peripheral immune system ( + and CD8 + T cells, including T helper 1 (T H 1) and T H 17 subsets, together with B cells and innate immune cells, subsequently cross the blood-brain barrier (BBB) and infiltrate the CNS

In recent years, long-acting GLP-1 RAs such as liraglutide, dulaglutide, semaglutide, and the dual GIP/GLP-1 receptor agonist tirzepatide have become widely used