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These results indicate that FGF21 plays a key role in regulating the expression of genes involved in hepatic lipid homeostasis and that activation of FGF21 activity could prove to be a significant tool in the treatment of the disrupted metabolic status in diabetic individuals

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48 Taken together, elevated TMAO increases patient risk for developing atrial fibrillation, which becomes even more serious when considering the pro-thrombotic effects of TMAO, which may exacerbate the clinical manifestations of arrhythmias

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compared healthy (high-fiber) and unhealthy (high-cholinergic) diets and found that the TMAO produced by the diet is only partially related to the degree of atherosclerosis, because a high-cholinergic diet may work through a series of pro-inflammatory and platelet activations, rather than single mediators ( ApoE / mice ( Table 2 The positive or non-effects of trimethylamine-N-oxide (TMAO) on atherosclerosis demonstrated via clinical and non-clinical experiments

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