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found that the GM composition of PCOS patients with IR differed from that of PCOS patients without IR and healthy women ( When GM is disrupted by various factors such as diet, medication, and stress, the number of beneficial bacteria decreases while that of harmful bacteria increases

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The most studied example of this is HDLs ability to bind to the plasma membrane and through cell signaling mobilize cholesterol from intracellular stores in organelles to the plasma membrane for efflux