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The increasing use of GLP-1 RAs could partially be driven by the large unmet demand for effective/efficient treatment in the obese population

First, falling plasma glucose concentrations fail to elicit a corresponding decrease in insulin secretion in patients taking insulin or insulin secretagogues

Practical takeaway: This is why cycle length matters

Some effects, such as a rapid heartbeat, occur within minutes of use, while others, such as oral thrush, may develop after several days or weeks of regular use