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In a methylphenidate-induced rat model, topiramate significantly decreased the levels of IL-1, TNF-, and brain-derived neurotrophic factor in isolated hippocampal cells (Motaghinejad et al., 2016)

Acetyl-L-carnitine is used for tiredness related to getting older, tiredness related to a disease called multiple sclerosis, a muscle wasting disease called amyotrophic lateral sclerosis, high levels of activity in children with the genetic condition fragile-X syndrome, and attention deficit-hyperactivity disorder (ADHD)

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OA is a degenerative disorder affecting the entire joint structure

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