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5 The mechanisms linking obesity to hypertension include overactivation of the sympathetic nervous system, activation of the renin-angiotensin-aldosterone system, endothelial dysfunction, fatty kidney, sleep apnea, and inflammation

This distinction suggests that pyroptosis may represent a more prioritized therapeutic target in the early or acute stages of disease, whereas ferroptosis inhibition strategies may hold unique value in the chronic phase or in patients with comorbid conditions such as iron overload or diabetes

Many researchers establish a rotation pattern, moving systematically between sites

& Monteggia, L

O., Abdullah, K