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doi: 10.1016/j.freeradbiomed.2017.08.009

PMCID:PMC6377501

In this study Epitalon increased telomere length in human cell lines, and the authors attributed this to an upregulation of telomerase or, alternatively, to the ALT pathway (alternative lengthening of telomeres)

Full IGF-1 receptor density recovery requires 68 weeks after a 46 week daily dosing cycle, with receptor gene expression rebounding first (23 weeks) followed by restoration of cell surface receptor density and post-receptor signaling sensitivity (46 weeks total)