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Taking ibuprofen alongside other nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin or naproxen can raise the risk of gastrointestinal issues such as ulcers and bleeding

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doi: 10.3389/fphys.2020.00446 95

Jastreboff et al, evaluating Tirzepatide (a GLP-1) found that a sequential dose (from 5 mg to 10 mg to 20 mg/once weekly over 72 weeks) produced an average weight loss of 20.6 kg (19.6%) at 72 weeks evaluation