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Infusion of obese Zucker rats as well as lean littermates with AICAR decreases plasma TAG and FA concentrations, as well as glycerol turnover (37), whereas mice lacking the AMPK-alpha2 subunit have been shown to have increased adiposity and weight gain (98, 131)

It has a free sulfhydryl group (-SH) from the cysteine amino acid that can donate electrons to neutralize free radicals and reactive oxygen species

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USA , 116 , 9433-9442, doi: Zhang, J., Pavlova, N