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4. Trailokya A et al. Calcium and Calcium Salts. 5. Welch A et al. Nutrients. 2017;9(11):1189. 6. Jach ME et al. Metabolites. 2022;12(1):63. 7. Ma C et al. Curr Res Food Sci. 2023;7:100555

The first part is the fraction of drug absorbed across the gut wall (f)

Wegovy and Zepbound [tirzepatide] will be out of a persons system in a few weeks, while Saxenda [liraglutide], because its a daily medication, will be out in a few days, says Garcia-Webb

Neither peptide has received regulatory approval as a therapeutic agent from the FDA, EMA, or other major regulatory bodies

Going back to the IEL cells for a moment, in Crohns disease and ulcerative colitis (UC) these cells can start to attack the gut lining itself, this further creates a cytotoxic environment, which can further exacerbate IELs to produce pro-inflammatory proteins, this can lead to a compromised intestinal lining, along with alterations in the gut microbiome