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FIGURE 3 The initiation of pyroptosis depends on the sensing of the extracellular microenvironment, primarily through TLRs (Nystrm et al., 2013) or the cytosolic space via NOD-like receptors (NLRs) (Qiu et al., 2017)

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In addition to GIPs role in promoting lipid storage in adipocytes 140 , the GIP receptor (GIPR) is found in neurons of the ARC, dorsomedial nucleus (DMH), and paraventricular nucleus of the hypothalamus 141