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SOUL trial: Oral semaglutide demonstrates a 14% reduction in risk of major adverse CV events owenhaskins Oct 24, 2024 2 min read Headline results from the SOUL cardiovascular outcomes trial show the trial achieved its primary objective by demonstrating a statistically significant and superior reduction in major adverse cardiovascular events (MACE) of 14% for people treated with oral semaglutide compared to placebo (based on treatment policy estimand: treatment effect regardless of treatment adherence)

The -enatides are short-acting and primarily decrease postprandial (post-meal) blood glucose, with limited impact on fasting glucose

(2) the precise convergence of its multiple molecular targets (e.g., GSK-3, inositol pathway, mitochondrial function) on a unified mechanism of action

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