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Purified CBD in psychiatric conditions (psychosis, schizophrenia and bipolar disorder) Many preclinical studies have demonstrated the role of pure CBD in ameliorating the symptoms of psychosis, and in models of schizophrenia (such as reducing stereotypy, hyperlocomotion, normalisation of social withdrawal and cognitive improvements) involving CB 1 and CB 2 , 5-HT1A receptor and neurogenesis factors [67,68,69]