My only side effects have been: some mild constipation (take mg citrate to fight that), very mild diarrhea , heartburn that increased as the dosage mg increased, although eating TUMS like candy took care of it (but expensive because I insist on having the TUMS that taste good to me), and injection site reactions (similar to a mosquito bite 3 days, managed with OTC cortisol cream and/or OTC roll-on 4% lidocaine)
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The current evidence points to retatrutide being safe overall, but monitoring by a healthcare provider during treatment is still important
Ongoing use beyond twelve weeks continues to produce improvements, particularly for hair density changes, which require the longest timeline to manifest visibly
Paying attention to when changes occur can give you useful insight into what is affecting your skin