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Once activated, AMPK triggers a cascade of metabolic responses that mimic the physiological effects of rigorous physical exercise or caloric restriction, enhancing glucose uptake and promoting the oxidation of fatty acids to generate new ATP

Biochim et Biophys Acta (BBA) Mol Cell Res 1813:508520 Mandal D, Mazumder A, Das P, Kundu M, Basu J (2005) Fas-, caspase 8-, and caspase 3-dependent signaling regulates the activity of the aminophospholipid translocase and phosphatidylserine externalization in human erythrocytes

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Its main pathological hallmark constitutes demyelinating lesions that accumulate within the central nervous system (CNS) (Popescu et al., 2013