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BMI at 2-year follow-up, change in BMI from baseline, odds of reducing BMI category, and the need for treatment augmentation were exploratory outcomes

GLP-1 or GLP-1MK-801 (1 M in aCSF) was bath-applied for 25 min, with recording only being conducted during the first 10 min, at which point a maximum and stable change in fluorescence was achieved

With insurance coverage varying significantly and Medicare not covering weight loss medications, many patients explore cash-pay alternatives through various access pathways

Baseline information on included trials can be found in Supplementary Table S3

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