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Retatrutide (Retara), a triple GIP/GLP-1/glucagon agonist, produced the highest mean weight loss in clinical trials (24.2% at 48 weeks)
While cell lines have informed (sub)cellular pharmacology, they do not allow endogenous GPCRs to be interrogated, nor do they replicate the tissue environment where heterogeneity and cell-cell interactions are critical for shaping signaling responses 3,4,5,6
Adipose tissue is also biologically active, releasing pro-inflammatory cytokines that can lead to chronic inflammation, which in turn elevates the risk of several cancers and liver diseases
V., Price, K
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