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First, quick background: the growth hormone axis

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Life Sci 81:272279

And over-the-counter L-carnitine supplements are significantly cheaper than the compounded blend premium

PL7737 has comparable potency to small molecule agonists (MK-0493, bivamelagon) that were inefficacious in general obese populations and RM-718 is less potent on MC3R and MC4R than setmelanotide, raising concerns for potential lack of efficacy in future general obesity trials