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doi:10.1016/S0140-6736(19)31149-3 353

FIN56, an inducer of ferroptosis derived from CIL56, promotes endogenous antioxidant activity by either facilitating the degradation of GPX4 or binding to and activating squalene synthase (SQS), which results in the depletion of CoQ 10 [135]

Animal models have demonstrated how SFN can alter microbiota composition, correlating with behavioral improvements, and suggest that targeting gut bacteria may be one of the mechanisms of benefit

However, there is some evidence that it might benefit people exposed to brief periods of severe physical exercise (marathon runners) or cold environments (skiers and soldiers in subarctic conditions)

The VPA -oxidation metabolite 2-en-VPA is another agent that can promote cerebral oedema when it accumulates in brain and plasma