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After excluding studies for misclassification or other biases, the relative risk of cardiovascular events with sulfonylureas was consistently elevated (relative risk [RR] range: 1.16 to 1.55) compared to metformin, with the exception of one trial comparing sulfonylurea plus metformin to metformin alone, which found no difference in all cause mortality (26)

It also leads to conversations about the benefits and limitations of using Ozempic for similar goals

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If you want to eventually taper off and maintain results Nooms behavioral platform is purpose-built for that transition