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Appetite suppression typically emerges first, with noticeable hunger reduction often reported before significant scale changes

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The study utilized advanced multi-omics approaches, including single-cell RNA sequencing of the heart and liver, as well as cardiac, hepatic and plasma proteomics, to explore underlying mechanisms

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Additionally, polyphenols may modulate the biosynthesis of pro-inflammatory lipid mediators by affecting the enzymatic activities involved in inflammation, thereby contributing to their anti-inflammatory action (270, 273)