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cytosolic calcium instability drives mitochondrial calcium overload, destabilizes membrane potential, increases permeability transition pore opening, and amplifies ROS generation

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(PubMed) Song X, Qu H, Yang Z, Rong J, Cai W, Zhou H

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The findings imply that GLP-1 may have an impact on reproductive hormones, pointing to possible treatment approaches for type 2 diabetes and obesity-related hypogonadism in males (105)