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Clinical, Cosmetic and Investigational Dermatology, 10, 147153

Route of Elimination Following a single intravenous dose, 73.1 +/- 16% of the dose was excreted in the urine during the 0-24 hour interval

Heart rate increases were dose-dependent and followed a consistent pattern across all treatment groups

Excretion Pathways Limited data on combined excretion indicates[21]: Primarily renal elimination of peptide fragments from all components Hepatic metabolism contributes to overall clearance Copper recycling through normal physiological pathways (GHK-Cu component) No evidence of accumulation in chronic dosing studies of individual components BPC-157 detectable in urine for up to 4 days

Polyclonal antibodies against -actin, laminB, phospho-GSTP (Ser184), His-tag, and Flag-tag were from Bioworld Biotechnology (Minneapolis, MN, USA)